• in the Dune Chronicles (DC) everyone believed the Bene Tleilaxu to be amoral genetic wizards; in Dune: House Atreides (D:HA), it's obvious that they're religious zealots, something that wasn't found out until Odrade discovered that.
• The Guild would never allow robotic shuttles.
• The Baron's "disease" in D:HA was given to him by Gaius Helen Mohiam, how is it that the Beast Rabban in Dune is said to suffer the same fate? Also, since the Bene Gesserit punishments are designed to teach a lesson, what lesson did the Baron learn?